We are excited to share a new publication from the research funded by Open Medicine Foundation (OMF). Jonas Bergquist, MD, PhD, OMF Chief Medical Officer and Director of the OMF-supported ME/CFS Collaborative Research Center at Uppsala University, and colleagues, have published a study: ‘Analysis of tryptophan metabolites and related compounds in human and murine tissue: development and validation of a quantitative and semi-quantitative method using high resolution mass spectrometry.’ Read now!
Research Summary: From the Desk of Dr. Jonas Bergquist:
“Our recent study, published in the Analytical Methods Journal, aimed to investigate the levels of tryptophan metabolites in human plasma using an advanced technique called high-resolution mass spectrometry. Tryptophan is an essential amino acid that plays a crucial role in various metabolic processes. Disruptions in its pathway have been implicated in several diseases.
Our goal is to incorporate this methodology in our upcoming study to analyze plasma samples from people diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and comparing them to samples from healthy individuals, to uncover potential mechanisms involved in the development of this debilitating disease. This study supports the Kynurenine trap model for ME/CFS, shedding light on the pathogenesis of the condition. We hope that our findings will contribute to a deeper understanding of ME/CFS.”
Open Medicine Foundation is committed to funding groundbreaking research and publications like this, which have the potential to improve the lives of millions of people with ME/CFS and Long COVID. Your support is crucial in accelerating research, advancing our understanding of these complex conditions, and ultimately finding effective diagnostics and treatments.
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