Autonomic nervous system
The autonomic nervous system controls involuntary actions in the body like heart rate, blood pressure, digestion, and more.
In ME/CFS, it is widely accepted that the autonomic nervous system doesn’t function correctly, which is called dysautonomia. This contributes to some of the major symptoms of ME/CFS, including fatigue.
OMF’s clinical trial, the Life Improvement Trial (LIFT), is investigating two drugs: pyridostigmine and low-dose naltrexone. Pyridostigmine has been used off-label to manage dysautonomia, so the LIFT may, in part, help to address dysautonomia in ME/CFS. Read more about the trial on our website: https://www.omf.ngo/the-life-improvement-trial/.